Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay

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Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay.

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Practice Lesson of the week Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay

Serum vitamin B-12 concentrations are measured to assess the presence of its deficiency in patients presenting with haematolological, neurological, and neuropsychiatric abnormalities. Replacement therapy is instituted promptly, particularly to prevent irreversible neurological and cognitive dysfunction. I present two cases with paradoxical vitamin B-12 results, which highlight the fallacies of ...

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Nitrous oxide-induced vitamin B(12) deficiency.

Two patients with asymptomatic vitamin B(12) deficiency developed a peripheral neuropathy 6-7 weeks after exposure to nitrous oxide during general anaesthesia, and 3 and 11 days after receiving cyclophosphamide. The serum B(12) concentration was less than 20 pmol/l and the symptoms resolved after B(12) replacement. We believe that the neurological symptoms were triggered by exposure to nitrous ...

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[Neurological manifestations in Vitamin B 12 deficiency].

Vitamin B-12 deficiency is a common problem encountered in developing countries of the world. In Europe and North America it is frequently encountered in the elderly and in people whose diets are compromised such as alcoholics. Recent data has shown that cobalamin deficiency may occur in 5% to 40% of the general population. The prevalence as stated earlier is higher in the elderly and in nursin...

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Role of third serum vitamin B 12 binding protein in vitamin B 12 transport.

A third vitamin B(12) binding protein present in normal serum has been shown to participate in transport of labelled vitamin B(12) absorbed from the gut. All three vitamin B(12) binding proteins in serum were labelled at the same time after oral administration of vitamin B(12), implying that "free" vitamin B(12) reached the portal blood from the gut mucosa.

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ژورنال

عنوان ژورنال: BMJ

سال: 2006

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.333.7564.385